| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371449 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of 4-aminopyrimidine-5-carbaldehyde oxime was discovered to have potent VEGFR-2 inhibitory activity. Described here are the chemistry for analogue synthesis and SAR study results. The PK properties, kinase profiling, and in vivo efficacy study for compound 4b are also discussed.
Graphical abstractA series of 4-aminopyrimidine-5-carbaldehyde oximes was discovered to have potent VEGFR-2 inhibitory activities. Described here are the chemistry for analogue synthesis and SAR study results. The PK properties, kinase profiling, and in vivo efficacy study for compound 4b are also discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shenlin Huang, Ronghua Li, Kenneth R. LaMontagne, Lee M. Greenberger, Peter J. Connolly,