| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371459 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The bioisosteric replacement of the indole core of CRTH2 antagonists using thienopyrroles was investigated, resulting in potent antagonists with good selectivity over DP1. Early ADME/PK assessment of this chemotype demonstrated bioavailability in mice.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dominique Bonafoux, Ayome Abibi, Brian Bettencourt, Andrew Burchat, Anna Ericsson, Christopher M. Harris, Tegest Kebede, Michael Morytko, Michael McPherson, Grier Wallace, Xiaoyun Wu,