| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371462 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of quinoline derivatives was synthesized as potential bioisosteric replacements for the benzothiadiazine moiety of earlier Hepatitis C NS5B polymerase inhibitors. Several of these compounds exhibited potent activity in enzymatic and replicon assays.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Douglas K. Hutchinson, Charles A. Flentge, Pamela L. Donner, Rolf Wagner, Clarence J. Maring, Warren M. Kati, Yaya Liu, Sherie V. Masse, Tim Middleton, Hongmei Mo, Debra Montgomery, Wen W. Jiang, Gennadiy Koev, David W.A. Beno, Kent D. Stewart,