| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371489 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones were evaluated as corticotropin-releasing factor-1 receptor antagonists. The synthesis, SAR studies and pharmacokinetic evaluation of these analogs are described herein.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists](/preview/png/1371489.png "First Page Preview: Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists")
Authors
Carolyn D. Dzierba, Thais M. Sielecki, Argyrios G. Arvanitis, Amy Galka, Tricia L. Johnson, Amy G. Takvorian, Maria Rafalski, Padmaja Kasireddy-Polam, Shikha Vig, Bireshwar Dasgupta, Ge Zhang, Thaddeus F. Molski, Harvey Wong, Robert C. Zaczek,