| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371498 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives has been prepared and subsequently evaluated with regards to the inhibition of 5-LOX/COX. Structure optimization furnished derivatives with promising in vitro activity as dual 5-LOX/COX inhibitors with submicromolar IC50 values for inhibition of 5-LOX and COX-1, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Finn K. Hansen, Mehdi Khankischpur, Ibrahim Tolaymat, Renata Mesaros, Gerd Dannhardt, Detlef Geffken,