| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371501 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The synthesis and evaluation of antiplasmodial activity of benzothiazole, benzimidazole, benzoxazole and pyridine analogues of amodiaquine is hereby reported. Benzothiazole and benzoxazole analogues with a protonatable tertiary nitrogen atom possessed excellent activity against the W2 and K1 chloroquine resistant strains of Plasmodium falciparum, with IC50s ranging from 7 to 22 nM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dennis S.B. Ongarora, Jiri Gut, Philip J. Rosenthal, Collen M. Masimirembwa, Kelly Chibale,