| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371513 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Lead optimization efforts that employed structure base drug design and physicochemical property based optimization leading to the discovery of a novel series of 4-methylpyrido pyrimidinone (MPP) are discussed. Synthesis and profile of 1, a PI3Kα/mTOR dual inhibitor, is highlighted.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Phuong T. Le, Hengmiao Cheng, Sacha Ninkovic, Michael Plewe, Xiaojun Huang, Hai Wang, Shubha Bagrodia, Shaoxian Sun, Daniel R. Knighton, Caroline M. LaFleur Rogers, Andrew Pannifer, Samantha Greasley, Deepak Dalvie, Eric Zhang,