| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371540 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Histone deacetylase inhibitors (HDACi) pleiotropy is largely due to their nonselective inhibition of various cellular HDAC isoforms. Connecting inhibition of a specific isoform to biological responses and/or phenotypes is essential toward deconvoluting HDACi pleiotropy. The contribution of classes I and II HDACs to the antileishmanial activity of HDACi was investigated using the amastigote and promastigote forms of Leishmania donovani. We observed that the antileishmanial activities of HDACi are largely due to the inhibition of HDAC6-like activity. This observation could facilitate the development of HDACi as antileishmanial agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Quaovi Sodji, Vishal Patil, Surendra Jain, James R. Kornacki, Milan Mrksich, Babu L. Tekwani, Adegboyega K. Oyelere,