| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371567 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A novel series of pyrazole sEH inhibitors is reported. Lead optimization efforts to replace the aniline core are also described. In particular, 2-pyridine, 3-pyridine and pyridazine analogs are potent sEH inhibitors with favorable CYP3A4 inhibitory and microsomal stability profiles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ho Yin Lo, Chuk C. Man, Roman W. Fleck, Neil A. Farrow, Richard H. Ingraham, Alison Kukulka, John R. Proudfoot, Raj Betageri, Tom Kirrane, Usha Patel, Rajiv Sharma, Mary Ann Hoermann, Alisa Kabcenell, Stéphane De Lombaert,