| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371589 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of N-substituted-3-[(2′-hydroxy-4′-prenyloxy)-phenyl]-5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure–activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B.
Graphical abstractNew prenylated pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rossella Fioravanti, Adriana Bolasco, Fedele Manna, Francesca Rossi, Francisco Orallo, Matilde Yáñez, Alberto Vitali, Francesco Ortuso, Stefano Alcaro,