| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371594 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of novel coumarin bisindole heterocycles were synthesized following an uncommon method and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model. Among 12 compounds tested, the compound 5e showed potent antihyperlipidemic activity and was found to decrease the plasma triglyceride levels (TG) by 55%, total cholesterol (TC) by 20%, accompanied by an increase in HDL-C/TC ratio by 42% in hyperlipidemic rats to a greater degree than some of the reference statins.
Graphical abstractThe discovery of new series of coumarin bisindoles as potential antidyslipidemic agents is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Koneni V. Sashidhara, Abdhesh Kumar, Manoj Kumar, Anuj Srivastava, Anju Puri,