| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371601 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
An efficient synthesis of [d-lysine]8cyclosporin A has been developed. Several analogs of [d-lysine]8cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC50 <200 nM, and are each â¥50-fold less immunosuppressive than cyclosporin A.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and biological evaluation of [d-lysine]8cyclosporin A analogs as potential anti-HCV agents](/preview/png/1371601.png "First Page Preview: Synthesis and biological evaluation of [d-lysine]8cyclosporin A analogs as potential anti-HCV agents")
Authors
Andrew Scribner, David Houck, Zhuhui Huang, Sarah Mosier, Michael Peel, Bernard Scorneaux,