| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371614 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Design and synthesis of cis-2,6-disubstituted N-arylsulfonyl morpholines as novel γ-secretase inhibitors for the potential treatment of Alzheimer’s disease (AD) is reported. Several different small alkyl groups are installed on the left-hand side to lower the CYP3A4 liability while maintaining excellent in vitro potency.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongmei Li, Ruo Xu, David Cole, John W. Clader, William J. Greenlee, Amin A. Nomeir, Lixin Song, Lili Zhang,