| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371618 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
New 6-substituted and 2,6-disubstituted pyridazinone derivatives were obtained starting from easily accessible alkyl furans by using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of this synthetic strategy. The new pyridazinone derivatives have been studied as vasorelaxant and antiplatelet agents. Analysis of biological data revealed the silyl ethers (4a–i) and N,O-dibenzyl derivatives (6g–i) as the most active compounds.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tamara Costas, Pedro Besada, Alessandro Piras, Laura Acevedo, Matilde Yañez, Francisco Orallo, Reyes Laguna, Carmen Terán,