Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371619 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The 5-HT1A receptor subtype is the most thoroughly studied serotonin receptor subtype. We report here the design, synthesis and characterization of two new fluorescent ligands for the 5-HT1A receptor. The new 1-arylpiperazine-based red-emitting fluorescent compound 6 displayed good binding affinity at the 5-HT1A receptor (Ki = 35 nM) and was able to label specifically the human 5-HT1A receptor stably expressed in CHO cells visualized using confocal laser scanning microscopy.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Enza Lacivita, Anna Carmela Masotti, Md. Jafurulla, Roopali Saxena, Nandini Rangaraj, Amitabha Chattopadhyay, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone, Marcello Leopoldo,