Article ID Journal Published Year Pages File Type
1371619 Bioorganic & Medicinal Chemistry Letters 2010 5 Pages PDF
Abstract
The 5-HT1A receptor subtype is the most thoroughly studied serotonin receptor subtype. We report here the design, synthesis and characterization of two new fluorescent ligands for the 5-HT1A receptor. The new 1-arylpiperazine-based red-emitting fluorescent compound 6 displayed good binding affinity at the 5-HT1A receptor (Ki = 35 nM) and was able to label specifically the human 5-HT1A receptor stably expressed in CHO cells visualized using confocal laser scanning microscopy.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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