Article ID Journal Published Year Pages File Type
1371628 Bioorganic & Medicinal Chemistry Letters 2010 5 Pages PDF
Abstract

The synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles as potent p38α mitogen-activated protein kinase inhibitors is described. The trisubstituted imidazole series was found to be more potent than the tetrasubstituted imidazole series. Many of these compounds show low-nanomolar activities in the isolated p38α MAP kinase inhibition assay. The structure–activity relationships between these two series are different and not comparable.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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