Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371628 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles as potent p38α mitogen-activated protein kinase inhibitors is described. The trisubstituted imidazole series was found to be more potent than the tetrasubstituted imidazole series. Many of these compounds show low-nanomolar activities in the isolated p38α MAP kinase inhibition assay. The structure–activity relationships between these two series are different and not comparable.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefan Laufer, Dominik Hauser, Thomas Stegmiller, Claudia Bracht, Kathrin Ruff, Verena Schattel, Wolfgang Albrecht, Pierre Koch,