| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371637 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A simple and rapid NMR method is described to determine the log P of pharmaceutical agents. This method is highly versatile and efficient, because it does not require the use of deuterated solvents or the addition of any internal/external standards to the sample. We demonstrate that log P can be accurately measured using NMR for pharmaceutical agents with known log P values. Our proposed method is made possible by the combination of state-of-the-art NMR techniques including the solvent concentration reference and robust solvent suppressions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Huaping Mo, Kathryn M. Balko, David A. Colby,