| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371641 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Novel hygromycin A derivatives bearing a variety of functionalized aminocyclitol moieties have been synthesized in an effort to increase the antibacterial activity and drug-like properties of this class of agents. A systematic study of the effect of alkylation and removal of the hydroxyls of the aminocyclitol directed us to a series of alkylated aminocyclitol derivatives with improved Gram-positive activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael S. Visser, Kevin D. Freeman-Cook, Steven J. Brickner, Katherine E. Brighty, Phuong T. Le, Sarah K. Wade, Rhonda Monahan, Gary J. Martinelli, Kyle T. Blair, Dianna E. Moore,