Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371651 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of N,N-disubstituted-N′-[1-aryl-1H-pyrazol-5-yl]-methnimidamides was synthesized by a newly developed microwave reaction and their antiproliferative activities were evaluated. Microwave irradiation of 5-amino-1,3-disubstituted pyrazoles with various amide solvents in the presence of POCl3 provided the corresponding 2a–2k, 3a–3c, and 4a–4f in good to excellent yields. The obtained methnimidamides were tested against NCI-H661, NPC-TW01, and Jurkat cancer cell lines and the results indicated that compounds 2d and 2e were the most potent with IC50 values in low micromolar range.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kaung-Min Cheng, Yu-Ying Huang, Jiann-Jyh Huang, Kimiyoshi Kaneko, Masayuki Kimura, Hiroyuki Takayama, Shin-Hun Juang, Fung Fuh Wong,