| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371689 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
A series of dimeric phloroglucinol compounds were synthesized in a single step using commercially available phloroglucinol and methanesulfonic acid. Based on the reported anticancer activity of plant derived dimeric phloroglucinols, these synthesized compounds were evaluated for their in vitro anti-proliferative activities against various cancer cell lines. Several compounds demonstrated in vitro cytotoxic effects across a wide array of tumor cell types. The compound 29 with pyridin-3-yl group on linker methylene and two diisovaleryl phloroglucinol moieties was found to be the most active in all the five cancer cell lines having a low IC50 of 5.5 μM in colon cancer cell lines (HCT116).
Graphical abstractA one pot synthesis of dimeric phloroglucinol compounds was achieved from commericially available phloroglucinol. The synthesized compounds were evaluated for their in vitro anti-proliferative activities against various cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide
