| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371693 | Bioorganic & Medicinal Chemistry Letters | 2012 | 8 Pages |
Abstract
Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and Log D lead to the identification of orally bioavailable, potent antagonists with improved selectivity over hERG.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Patrick Hanrahan, James Bell, Gillian Bottomley, Stuart Bradley, Phillip Clarke, Eleanor Curtis, Susan Davis, Graham Dawson, James Horswill, John Keily, Gary Moore, Chrystelle Rasamison, Jason Bloxham,