Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371724 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of C-2 pyrroloquinoline analogs designed to improve aqueous solubility were examined for herpesvirus polymerase and antiviral activity. Several analogs were identified that maintained the antiviral activity of the previous development candidate against HCMV, HSV-1 and VZV, but with significantly improved aqueous solubility.
Graphical abstractThe synthesis of pyrroloquinoline analogs at C-2 with broad-spectrum anti-herpetic activity and improved solubility are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James A. Nieman, Sajiv K. Nair, Steven E. Heasley, Brenda L. Schultz, Herbert M. Zerth, Richard A. Nugent, Ke Chen, Kevin J. Stephanski, Todd A. Hopkins, Mary L. Knechtel, Nancee L. Oien, Janet L. Wieber, Michael W. Wathen,