| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371725 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Two cyclopeptidic Smac mimetics, 2 and 3, were designed and synthesized. These two compounds bind to XIAP and cIAP-1/2 with low nanomolar affinities, and restore the activities of caspase-9 and caspase-3/-7 inhibited by XIAP. Compound 2 potently inhibits cancer cell growth and is 5–8 times more potent than the initial lead compound.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haiying Sun, Liu Liu, Jianfeng Lu, Su Qiu, Chao-Yie Yang, Han Yi, Shaomeng Wang,