Synthesis of novel benzocoumarin derivatives as lipid lowering agents

A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Preliminary screening indicates compound 4 as potential lead with significant lipid lowering and antioxidant activities. The study revealed that such attempts on benzocoumarin-based pharmacophores which is a biologically important scaffold might result in identification of new lead for anti-dyslipidemia.

Graphical abstractNovel benzocoumarin derivatives were synthesized and their hypolipidemic activity was evaluated resulting in identification of a potential lead.Figure optionsDownload full-size imageDownload as PowerPoint slide