Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371736 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
SSR149415 was the first non-peptide vasopressin-(V1b) receptor antagonist reported. It has been used to probe the role of V1b receptors in animal models of depression, aggression, and stress-anxiety, and was progressed to clinical trials for the treatment of depression. Due to the interest in V1b receptors as a therapeutic target and the growing use of SSR149415 in preclinical research, we developed a method to label SSR145419 with carbon-11 and have studied its pharmacokinetics in non-human primates using positron emission tomography.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Matthias Schönberger, Carmine Leggett, Sung Won Kim, Jacob M. Hooker,