| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371740 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
1H-Pyrazolo[4,3-d]pyrimidines are a class of potent and selective second generation phosphodiesterase 5 (PDE5) inhibitors. This work explores the potency, selectivity and efficacy of 1-(2-ethoxyethyl)-1H-pyrazolo[4,5-d]pyrimidines as PDE5 inhibitors resulting in the advancement of a clinical candidate.
Graphical abstractThis work explores the potency, selectivity and efficacy of 1-(2-ethoxyethyl)-1H-pyrazolo[4,5-d]pyrimidines as PDE5 inhibitors resulting in the advancement of a clinical candidate.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Michael B. Tollefson, Brad A. Acker, E.J. Jacobsen, Robert O. Hughes, John K. Walker, David N.A. Fox, Michael J. Palmer, Sandra K. Freeman, Ying Yu, Brian R. Bond,