Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371746 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
The synthesis, structure–activity relationship and modeling of a series of 5-substituted-N-aryl pyridazinone based p38α inhibitors are described. In comparing the series to the similar N-aryl pyridinone series, it was found that the pyridazinones maintained a weaker interaction to the p38 enzyme, and therefore showed generally weaker binding than the pyridinones.
Graphical abstractThe synthesis, structure–activity relationship and modeling of a series of 5-substituted-N-aryl pyridazinone based p38α inhibitors are described. In comparing the series to the similar N-aryl pyridinone series, it was found that the pyridazinones maintained a weaker interaction to the p38 enzyme, and therefore showed generally weaker binding than the pyridinones.Figure optionsDownload full-size imageDownload as PowerPoint slide