| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371750 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
High-throughput screening identified compound 1 as a potent P2X7 receptor antagonist suitable for lead optimisation. Structure–activity relationships (SAR) of a series of (1H-pyrazol-4-yl)acetamides were investigated and compound 32 was identified as a potent P2X7 antagonist with enhanced potency and favourable physicochemical and pharmacokinetic properties.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laura J. Chambers, Alexander J. Stevens, Andrew P. Moses, Anton D. Michel, Daryl S. Walter, David J. Davies, David G. Livermore, Elena Fonfria, Emmanuel H. Demont, Mythily Vimal, Pam J. Theobald, Paul J. Beswick, Robert J. Gleave, Shilina A. Roman,