Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371751 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Steroidal bivalent ligands were designed on the basis of the described closer proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). The syntheses of seven progesterone–adenine hybrids were described. Their abilities to inhibit P-glycoprotein-mediated daunorubicin efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein were evaluated versus progesterone.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Waël Zeinyeh, Ghina Alameh, Sylvie Radix, Catherine Grenot, Charles Dumontet, Nadia Walchshofer,