| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371780 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The N-acetyl glucosaminosides of shikonin/alkannin were synthesized by chemical glycosylation, which provided an ideal approach to resolve the mixture of enantiomeric shikonin and alkannin co-existed in the Chinese herbs. The glycosylated shikonin and alkannin exhibited stronger binding activity to human telomeric G-quadruplex DNA than their parent structures. This research indicated that glycosylation of natural product with amino sugars is an effective strategy to improve their DNA-binding affinity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hao He, Li-Ping Bai, Zhi-Hong Jiang,