| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371781 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A praziquantel analog 10-hydroxy praziquantel and eight praziquantel/peroxide conjugates were synthesized. The biological activity of these compounds was evaluated against juvenile and adult stages of Schistosoma japonicum. Unlike praziquantel, 10-hydroxy praziquantel exhibits activity against both juvenile and adult Schistosoma japonicumin. All hybrid compounds displayed modest to significant worm killing activity. The present study has important significance for the development of hybrid antischistosomal drugs.
Graphical abstractPraziquantel derivatives with activity against both juvenile and adult Schistosoma j. in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wen-wen Duan, Si-jie Qiu, Yue Zhao, Huan Sun, Chunhua Qiao, Chao-ming Xia,