Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371782 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joaquín Pastor, Julen Oyarzabal, Gustavo Saluste, Rosa María Alvarez, Virginia Rivero, Francisco Ramos, Elena Cendón, Carmen Blanco-Aparicio, Nuria Ajenjo, Antonio Cebriá, M.I. Albarrán, David Cebrián, Ana Corrionero, Jesús Fominaya, Guillermo Montoya,