| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371782 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Joaquín Pastor, Julen Oyarzabal, Gustavo Saluste, Rosa María Alvarez, Virginia Rivero, Francisco Ramos, Elena Cendón, Carmen Blanco-Aparicio, Nuria Ajenjo, Antonio Cebriá, M.I. Albarrán, David Cebrián, Ana Corrionero, Jesús Fominaya, Guillermo Montoya,