| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371787 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A series of analogues of deoxyandrographolide (1) transformed by Cunninghamella blakesleana AS 3.2004 were isolated and identified by spectral methods including 2D NMR. Among them, 3-oxo-17,19-dihydroxy-7,13-ent-labdadien-15,16-olide (9), 3-oxo-19-hydroxy-1,13-ent-labdadien-15,16-olide (16), 3-oxo-1β-hydroxy-14-deoxy-andrographolide (17) and 3-oxo-2β-hydroxy-14-deoxyandrographolide (18) are new compounds. And their structure–activity relationships (SAR) of inhibitory activity on LPS-induced NO production in RAW 264.7 macrophage cells were also discussed.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sa Deng, Bao Jing Zhang, Chang Yuan Wang, Yan Tian, Ji Hong Yao, Lei An, Shan Shan Huang, Jin Yong Peng, Ke Xin Liu, Xiao Chi Ma,