Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide

Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A–G (1–2 and 5–9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1–2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3–8 and 10–16 were tested against nitric oxide production in LPS and IFN-γ-induced RAW 264.7 murine macrophages, and their IC50 values ranged from 9.85 to 13.95 μg/ml.

Graphical abstractSixteen compounds including seven new compounds oxyphyllanene A–G (1–2 and 5–9) were isolated from Alpinia oxyphylla with IC50 values of 9.85–13.95 μg/ml against nitric oxide production.Figure optionsDownload full-size imageDownload as PowerPoint slide