| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371801 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
We prepared a 5-fluorodeoxyuridine (5-FdUrd) derivative possessing azide methyl group (N3-FdUrd) as a novel radiation-activated prodrug. The parent antitumor agent, 5-FdUrd, was released efficiently from N3-FdUrd by hypoxic X-irradiation. On the other hand, the activation of N3-FdUrd was suppressed upon X-irradiation under aerobic conditions. A biological assay using A549 cells revealed that the cytotoxicity of N3-FdUrd was significantly enhanced by hypoxic X-irradiation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kazuhito Tanabe, Jin Ishizaki, Yuichirou Ando, Takeo Ito, Sei-ichi Nishimoto,