| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371822 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A group of novel synthetic indoloisoquinolines was prepared and its potential as a novel series of small-molecule anti-malarial leads was assessed. The structure–activity relationship on variation of three distinct regions of chemical space was investigated. A lead compound was generated with an activity close to that observed for a known anti-malarial natural product, dihydrousambarensine, that shares the indoloisoquinoline template structure.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul Horrocks, Samantha Fallon, Laura Denman, Oliver Devine, Liam J. Duffy, Anthony Harper, Emma-Louise Meredith, Sandra Hasenkamp, Adam Sidaway, Daniel Monnery, Theresa R. Phillips, Steven M. Allin,