| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371825 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Marked inhibitory effects of hybrid liposomes (HL-n; n = 21, 23, 25) composed of 90 mol % l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol % polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and flow cytometric analyses revealed the induction of apoptosis by HL-n in both cells. It is noteworthy that HL-23 could inhibit the invasion and migration of U-2 OS cells on the basis of matrigel invasion assay and scratch wound assay, respectively.
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Related Topics
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Authors
Hideki Kitajima, Yuji Komizu, Ryuichi Ueoka,