| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371827 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
We designed and synthesized estrogen receptor (ER) degradation inducers 5, 6, and 7, which crosslink the ER and the cellular inhibitor of apoptosis protein 1 (cIAP1). Compounds 5, 6, and 7 induced cIAP1-mediated ubiquitylation of ERα resulting in its proteasomal degradation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yosuke Demizu, Keiichiro Okuhira, Hiromi Motoi, Akiko Ohno, Takuji Shoda, Kiyoshi Fukuhara, Haruhiro Okuda, Mikihiko Naito, Masaaki Kurihara,