Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371830 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
A new proline-rich cyclic octapeptide named stylissamide X (1) was isolated from an Indonesian marine sponge of Stylissa sp. as an inhibitor of cell migration from the guidance of wound-healing assay. The chemical structure of stylissamide X (1) was determined on the basis of spectroscopic analysis, and stereostructure of the amino acids were deduced by Marfey’s method. Compound 1 showed inhibitory activity against migration of HeLa cells in the ranges of 0.1–10 μM concentration through both wound-healing assay and chemotaxicell chamber assay, while the cell viability was maintained more than 75% up to 10 μM concentration of 1.
Graphical abstractA new proline-rich cyclic octapeptide named stylissamide X was isolated from an Indonesian marine sponge of Stylissa sp. as an inhibitor of cell migration from the guidance of wound-healing assay.Figure optionsDownload full-size imageDownload as PowerPoint slide