Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1371839 | Bioorganic & Medicinal Chemistry Letters | 2009 | 8 Pages |
Abstract
We describe design, syntheses and structure–activity relationships of a novel class of 4,6-disubstituted quinazoline glucokinase activators. Prototype quinazoline leads (4 and 5) were designed based on the X-ray analyses of the previous 2-aminobenzamide lead classes. Modifications of the quinazoline leads led to the identification of a potent GK activator (21d).
Graphical abstractThe discovery of a new lead structure of quinazoline class and the structure–activity relationships of quinazoline glucokinase activators are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tomoharu Iino, Yasuhiro Sasaki, Makoto Bamba, Morihiro Mitsuya, Akio Ohno, Kenji Kamata, Hideka Hosaka, Hiroko Maruki, Mayumi Futamura, Riki Yoshimoto, Sumika Ohyama, Kaori Sasaki, Masato Chiba, Norikazu Ohtake, Yasufumi Nagata, Jun-ichi Eiki,