| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371861 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6′-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2′-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1 μM.
Graphical abstractTwo series of O-spiro C-aryl glucosides have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Baihua Xu, Binhua Lv, Yan Feng, Ge Xu, Jiyan Du, Ajith Welihinda, Zelin Sheng, Brian Seed, Yuanwei Chen,