| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371890 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A new class of selective MMP-12 inhibitors have been identified via high throughput screening. Crystallization with MMP-12 confirmed the mode of binding and allowed initial optimization to be carried out using classical structure based design.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ian P. Holmes, Simon Gaines, Steve P. Watson, Olivier Lorthioir, Adam Walker, Suzanne J. Baddeley, Shane Herbert, Danielle Egan, Máire A. Convery, Onkar M.P. Singh, Jeffrey W. Gross, John M. Strelow, Robert H. Smith, Augustin J. Amour, David Brown,