Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists

The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the conformationally restricted 4-aminopiperidine ring found in several series of CCR5 antagonists.

Graphical abstractThe bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 4-aminopiperidine ring system found in several series of chemokine receptor CCR5 antagonists.Figure optionsDownload full-size imageDownload as PowerPoint slide