| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371921 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit.
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![Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit](/preview/png/1371921.png "First Page Preview: Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit")
Authors
Kristopher E. Boyle, Karen S. MacMillan, David A. Ellis, James P. Lajiness, William M. Robertson, Dale L. Boger,