| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371923 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Ultrasmall particles of iron oxide (USPIOs) coated with 3,3′-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethyleneglycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and magnetic characteristics were kept. Our novel conjugate targeted efficiently Jurkat cells (increase of 229% vs the control).
Graphical abstractUSPIO–peptidomimetic conjugate targeting Jurkat cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vincent Rerat, Sophie Laurent, Carmen Burtéa, Benoît Driesschaert, Vincent Pourcelle, Luce Vander Elst, Robert N. Muller, Jacqueline Marchand-Brynaert,