| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371962 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound’s potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.
Graphical abstractOur studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound’s potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dhimant Desai, SubbaRao V. Madhunapantula, Krishnegowda Gowdahalli, Arati Sharma, Raghavendragowda Chandagaludoreswamy, Karam El-Bayoumy, Gavin P. Robertson, Shantu Amin,