| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371978 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Analogs of the previously reported voltage gated sodium channel blocker CDA54 were prepared in which one of the amide functions was replaced with aromatic and non-aromatic heterocycles. Replacement of the amide with an aromatic heterocycle resulted in significant loss of sodium channel blocking activity, while non-aromatic heterocycle replacements were well tolerated.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pengcheng P. Shao, Feng Ye, Ann E. Weber, Xiaohua Li, Kathryn A. Lyons, William H. Parsons, Maria L. Garcia, Birgit T. Priest, McHardy M. Smith, John P. Felix, Brande S. Williams, Gregory J. Kaczorowski, Erin McGowan, Catherine Abbadie,