| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371979 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the benzylic position of benzamide were investigated to determine their effect on Nav1.7 inhibitory potency. The spirocyclobutyl substitution had the most significant enhancement on Nav1.7 inhibitory activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pengcheng P. Shao, Feng Ye, Ann E. Weber, Xiaohua Li, Kathryn A. Lyons, William H. Parsons, Maria L. Garcia, Birgit T. Priest, McHardy M. Smith, John P. Felix, Brande S. Williams, Gregory J. Kaczorowski, Erin McGowan, Catherine Abbadie,