| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371983 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Spiropiperidine naphthyridinone inhibitors of Staphylococcus aureus and Escherichia coli FabI have been prepared. Compounds 14a and 14c were identified as having sub-nanomolar E. coli FabI activity and are among the most potent FabI inhibitors yet described. The structural model of 14a bound to E. coli FabI is shown.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peter B. Sampson, Christine Picard, Sean Handerson, Teresa E. McGrath, Megan Domagala, Andrew Leeson, Vladimir Romanov, Donald E. Awrey, Dhushy Thambipillai, Elias Bardouniotis, Nachum Kaplan, Judd M. Berman, Henry W. Pauls,