| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1371986 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Thrombin aptamer was attempted to cage with Bhc (6-bromo-7-hydroxycoumarin-4-ylmethyl) group for controlling its specific affinity to target molecular through photolysis. By multiple-caging strategy, aptamer could be rendered biologically inert and partially restored with subsequently illumination. This provides a convenient method for photoregulating aptamer activity with exact spatiotemporal resolution.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
YiMing Li, Jing Shi, ZhaoFeng Luo, Hao Jiang, XiaoYun Chen, FengLiang Wang, Xu Wu, QingXiang Guo,